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In vivo extracellular recordings of neuronal firing have found that activation of 5-HT 2A/2C receptors using the nonselective agonist 2,5-dimethoxy-4-iodoamphetamine (DOI) both increased and decreased activity in subsets of normal spiking cells, 111,112 which could conceivably include both principal excitatory cells, such as pyramidal neurons, and regular spiking interneurons, such as those expressing the Ca 2+ -binding proteins calbindin and calretinin

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10.1002/1529-0131(199809)41:9 3.0.co;2-w Arthritis Rheum